Cardinale is a surname. Notable people with the surname include:
Claudia Cardinale (born 1938), Tunisian-born Italian actress
Gerald Cardinale (1934–2021), American politician
Igino Eugenio Cardinale (1916–1983), Italian Roman Catholic archbishop and diplomat
Lindsey Cardinale (born 1985), American singer
Marco Cardinale (born 1973), Italian sports scientist and administrator
Salvatore Cardinale (born 1948), Italian politician
Tina Cardinale-Beauchemin (born 1966), American athlete
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